1. Cabo Wabo Cantina: Founded by rock legend Sammy Hagar, Cabo Wabo Cantina is one of the most iconic nightlife spots in Cabo San Lucas. It offers live music, delicious cocktails, and a lively atmosphere.

2. Mandala: This nightclub is known for its energetic ambiance, featuring top DJs, themed parties, and a bustling dance floor. Mandala is a popular choice for those looking to dance the night away.

3. El Squid Roe: A landmark in Cabo San Lucas, El Squid Roe is a multi-level nightclub known for its wild parties, live entertainment, and vibrant atmosphere. It's a must-visit for those seeking an unforgettable nightlife experience.

4. The Rooftop at The Cape: Offering breathtaking views of the ocean and Cabo's iconic Arch, The Rooftop at The Cape is perfect for a more upscale and relaxed evening. It features craft cocktails, live music, and a sophisticated ambiance.

5. Señor Frogg´s Bar: Located in the heart of downtown Cabo San Lucas, The  Bar offers a laid-back atmosphere with live music, friendly staff, and a diverse selection of drinks.

6. La Vaquita Nightclub: This upscale nightclub boasts a stylish interior, VIP bottle service, and international DJs spinning the latest tracks. Pink Kitty is known for its high-energy parties and glamorous crowd.

7. Nowhere Bar: Situated on the marina, Nowhere Bar is a popular LGBTQ+ friendly nightclub featuring drag shows, themed parties, and a welcoming atmosphere for all.

8. Beach Clubs: Los Cabos is also home to several beach clubs where you can enjoy cocktails, music, and stunning ocean views during the day or into the evening. Popular options include Mango Deck Beach Club, SUR Beach House, and Nikki Beach.

Remember to check the latest schedules and events as the nightlife scene in Los Cabos is dynamic and can vary depending on the time of year and current trends. Additionally, it's essential to prioritize your safety and drink responsibly while enjoying the vibrant nightlife offerings in the area.